Article ID Journal Published Year Pages File Type
1355829 Bioorganic Chemistry 2015 7 Pages PDF
Abstract

•A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized.•The pUC19 plasmid DNA cleaving activity of Cu(II)−HGGH was investigated.•Cu(II)−HGGH (50 nM) converted a supercoiled DNA efficiently to a linear DNA.•The DNA cleavage took place in the presence of 500 μM H2O2/sodium ascorbate.

A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)−HGGH) was investigated. Cu(II)−HGGH showed bleomycin-like DNA cleaving activity and, at 50 nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500 μM H2O2/sodium ascorbate through an oxidative pathway.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , ,