Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1355829 | Bioorganic Chemistry | 2015 | 7 Pages |
•A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized.•The pUC19 plasmid DNA cleaving activity of Cu(II)−HGGH was investigated.•Cu(II)−HGGH (50 nM) converted a supercoiled DNA efficiently to a linear DNA.•The DNA cleavage took place in the presence of 500 μM H2O2/sodium ascorbate.
A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)−HGGH) was investigated. Cu(II)−HGGH showed bleomycin-like DNA cleaving activity and, at 50 nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500 μM H2O2/sodium ascorbate through an oxidative pathway.
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