Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1355895 | Bioorganic Chemistry | 2010 | 4 Pages |
Abstract
A rapid synthesis of 2′,3′-dideoxy-3′-fluoro-β-d-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
Graphical abstractA rapid synthesis of 2′,3′-dideoxy-3′-fluoro-beta-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ahmed Khalil, Christophe Mathé, Christian Périgaud,