Article ID Journal Published Year Pages File Type
1355903 Bioorganic Chemistry 2014 4 Pages PDF
Abstract

•An HIV-1 IN active site model was constructed using sub-domain X-ray and NMR structures.•The model was used to identify a furocoumarin system as a potential HIV-1 IN inhibitor.•The potential HIV-1 IN inhibitor and six structural analogues have been synthesised.•Some of the furocoumarin ligands exhibit low but statistically significant inhibition at 10 μM.

A series of seven novel, rationally designed N-substituted 3-{3,5-dimethylfuro[3,2-g]coumarin-6-yl}propanamides have been prepared as potential HIV-1 integrase (IN) inhibitors via a five-step pathway commencing with resorcinol and diethyl 2-acetylglutarate, and the HIV-1 IN inhibition potential of these compounds has been examined relative to raltegravir, a known HIV-1 IN inhibitor.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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