Synthesis, characterization and in vitro screening on bacterial, fungal and malarial strain of piprazinyl cyano biphenyl based compounds

•This research paper contain synthesis and microbial and malarial evolution of synthesized compounds.•Malarial activity is helpful for preparation more active malarial drugs.•Research work, helpful for synthesis of new chemical entity.

A series of eight 4′-[4-(3-substituted phenyl-acryloyl)-piprazin-1-ylmethyl]-biphenyl-2-carbonitrile were synthesized using 4′-Bromomethyl-biphenyl-2-carbonitrile and 4-Acetyl piprazine as a starting material. Furthermore, there has been some additional work done investigating effects of these derivatives on biological activities on bacterial, fungal and malarial strain. Synthesized compounds were characterized using FTIR, 1H NMR and 13C NMR spectrometry. These compounds shows good antimalarial, antibacterial and antifungal activity. In fact some compounds are more potent than standard drug quinine and Ampicillin some are with comparable activity with Ampicillin and quinine.

Graphical abstractBiological evolution like, bacterial, fungal and malarial study on piprazinyl cyano biphenyl based compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide