| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1356069 | Bioorganic Chemistry | 2009 | 6 Pages |
Abstract
The first total synthesis of 9-membered macrolide, stagonolide-F (3), starting from commercially available 1,5-pentane diol is reported. A combination of Jacobsen’s hydrolytic kinetic resolution (HKR) and Sharpless epoxidation is used for the creation of two stereogenic centers, while ring-closing metathesis (RCM) strategy was used for the construction of the lactone ring. The molecule synthesized exhibited potent antifungal, antibacterial and cytotoxic activities against all the tested strains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Arun Kumar Perepogu, D. Raman, U.S.N. Murty, Vaidya Jayathirtha Rao,