Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: Structural and biochemical implications

1,25-Dihydroxyvitamin D3-derivatives, containing probe at 1,3 and 11 positions affinity labeled VDR-LBD, yet only the 3-derivative inhibited growth of human keratinocytes stronger than the parent hormone: structural/biochemical implications are discussed.