| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1356378 | Bioorganic Chemistry | 2012 | 5 Pages |
We synthesized 12 derivatives of 2,3-bis(bromomethyl)quinoxaline with substituents at the 6- and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed antibacterial activity. The derivative 1g, which bears a trifluoromethyl group at the 6-position, showed the highest activity against Gram-positive bacteria, while 1c, which has a fluoro-group at the 6-position, showed the widest antifungal activity spectrum. However, only the derivative with an ethyl ester substitution, 1k showed activity against Gram-negative bacteria.
Graphical abstractTwelve 2,3-bis(bromomethyl)quinoxaline derivatives were synthesized and screened for antibacterial and antifungal activities.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Novel 2,3-bis(bromomethyl)quinoxaline derivatives were synthesized. ► Their antibacterial and antifungal activities have been reported. ► 6-(Trifluoromethyl)-2,3-bis(bromomethyl)quinoxaline had the highest antibacterial activity. ► 6-Fluoro-2,3-bis(bromomethyl)quinoxaline showed the widest antifungal activity spectrum.
