Chemical and biological evaluation of some new antipyrine derivatives with particular properties

Starting from 4-amino-antipyrine, six new compounds were synthesized and characterized. The new compounds contain moieties with particular properties, such are ionophore (benzo-15-crown-5), fluorescent (nitrobenzofurazan), stable free radical (nitroxide), or other types of biological active residues, like nitroderivatives, antipyrine or isoniazid residues. They were fully characterized by appropriate means (1H and 13C NMR, IR, UV–Vis, fluorescence, EPR, elemental analysis) and some of their biological properties were evaluated. Hydrophobicity (RM0, log P), total antioxidant capacity (TAC), and antimicrobial properties are also presented and discussed.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New antypirine derivatives synthesized and characterized. ► Contain moieties with particular properties. ► Biological activity evaluated.