| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1357636 | Bioorganic & Medicinal Chemistry | 2016 | 9 Pages |
Abstract
Some new platinum(II) complexes have been prepared, of general formula trans-[PtCl2(PPh3){NH(Bu)CH2Ar}], where the dimension of the Ar residue in the secondary amines has been varied from small phenyl to large pyrenyl group. The obtained complexes, tested in vitro towards a panel of human tumor cell lines showed an interesting antiproliferative effect on both cisplatin-sensitive and -resistant cells. For the most cytotoxic derivative 2a the investigation on the mechanism of action highlighted the ability to induce apoptosis on resistant cells and interestingly, to inhibit the catalytic activity of topoisomerase II.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lisa Dalla Via, Aída Nelly García-Argáez, Enzo Agostinelli, Daniela Belli Dell’Amico, Luca Labella, Simona Samaritani,