| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362853 | Bioorganic & Medicinal Chemistry | 2007 | 10 Pages |
Abstract
Photodynamic therapy (PDT) is an innovative treatment for several types of malignant and non-malignant disease. In the present study, ZnPcOCH3 was investigated on a human larynx-carcinoma cell line (Hep-2) for its use in PDT. This drug exhibited favourable properties as a photosensitizer in vitro because ZnPcOCH3 is able to penetrate efficiently in the cytoplasm of cultured cancer cells and is partially localized in lysosomes. The results show that ZnPcOCH3-PDT-induced apoptosis by caspase dependent pathway. The new compound shows a good photosensitizing efficiency in vitro on Hep-2 cells, encouraging further in vivo studies.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Edith I. Yslas, Edgardo N. Durantini, Viviana A. Rivarola,