| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1362866 | Bioorganic & Medicinal Chemistry | 2006 | 8 Pages |
Twenty-eight tetraketones (1–28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC50 = 2.61 μM), and 27 (IC50 = 3.19 μM) were found to be the most active compounds of the series, even better than both standards kojic acid (IC50 = 16.67 μM) and l-mimosine (IC50 = 3.68 μM). This study may lead to the discovery of therapeutically potent agents against clinically very important dermatological disorders including hyperpigmentation as well as skin melanoma.
Graphical abstractTwenty-eight tetraketones with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
