| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373680 | Carbohydrate Polymers | 2016 | 7 Pages |
•The effect of binary complexes was evaluated.•Chemical and physical stability under accelerated storage conditions were determined.•The complexes reduced the photodegradation process.•Results indicate that the complexes are promising matrices for drug delivery.
The effect of the formation of supramolecular binary complexes with β-cyclodextrin and maltodextrin on the chemical and physical stability of the polymorphs I and II of furosemide was evaluated in solid state. The solid samples were placed under accelerated storage conditions and exposed to daylight into a stability chamber for a 6-month. Chemical stability was monitored by high performance liquid chromatography, while the physical stability was studied by solid state nuclear magnetic resonance, powder X-ray diffraction and scanning electron microscopy. Changes in the physical appearance of the samples were evaluated. The studies showed a significant stabilizing effect of β-cyclodextrin on furosemide form II. Our results suggest that the complex formation is a useful tool for improving the stability of furosemide polymorphs. These new complexes are promising candidates that can be used in the pharmaceutical industry for the preparation of alternative matrices that improve physicochemical properties
