| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373698 | Carbohydrate Polymers | 2016 | 9 Pages |
•Mucoadhesive buccal tablets for local or systemic delivery of clonazepam were made.•CAR971/HPMC and POL/CSL mixtures were selected for drug loading.•Cogrinding with Randomly-methylated-βCD strongly increased drug release rate.•Tablets prepared with POL/CSL 70:30 w/w resulted the best for local drug delivery.•Kollicoat backing-layer assured unidirectional drug delivery for systemic action.
Two kinds of mucoadhesive buccal tablets of clonazepam (CLZ) were developed to provide, a prolonged local or systemic delivery respectively. Tablets prepared by direct compression of combinations of different polymers were tested for swelling, erosion and residence time properties. Carbopol 971P/hydroxypropylmethylcellulose and Poloxamer/chitosan mixtures were the best and were selected for drug loading. The effect of CLZ complexation with different cyclodextrins was investigated. Randomly-methylated-βCD (RAMEßCD) was the most effective, allowing 100% drug released increase from local-delivery buccal tablets. Kollicoat was the best among the tested backing-layers, assuring a unidirectional release from systemic-delivery buccal tablets (<0.8% drug released in simulated saliva after 24 h). In vitro permeation studies from coated-tablets showed that CLZ loading as RAMEßCD-coground enabled a 5-times increase in drug flux and permeability. Therefore, complexation with RAMEßCD was a successful strategy to improve the CLZ performance from buccal tablets for both local or systemic action.
