| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379153 | Carbohydrate Polymers | 2008 | 7 Pages |
Abstract
The aim of this research is to identify the cellular antioxidant effects of chitin oligosaccharides (NA-COS; Mw 229.21–593.12 Da) produced by acidic hydrolysis of crab chitin. The inhibitory effect of NA-COS on myeloperoxidase (MPO) activity in human myeloid cells (HL-60) and oxidation of DNA and protein in mouse macrophages (Raw 264.7) were identified. Furthermore, their direct radical scavenging effect by 2′,7′-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level were significantly increased in a time dependent manner, respectively. These results suggest that NA-COS act as a potent antioxidant in live cells.
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Authors
Dai-Nghiep Ngo, Moon-Moo Kim, Se-Kwon Kim,