Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379683 | Carbohydrate Polymers | 2008 | 5 Pages |
Abstract
Novel alginate/porous CaCO3 microparticle hybrid hydrogels are facilely fabricated by in-situ release of Ca2+ from CaCO3 microparticles induced by hydrolysis of d-glucono-δ-lactone to reduce pH. The mechanical strength of hybrid hydrogels is easily tunable by the alginate/CaCO3 weight ratio. IBU was adsorbed into the porous CaCO3 microparticles. The embedded porous CaCO3 microparticles endow alginate hydrogels versatile drug loading capability and sustained release, especially for less water-soluble substances. This methodology provides a novel way to create new hybrid hydrogels for biomedical applications.
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Authors
Chaoyang Wang, Hongxia Liu, Quanxing Gao, Xinxing Liu, Zhen Tong,