| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1384140 | Carbohydrate Research | 2012 | 9 Pages |
Regiospecifically sulfated heparan sulfate tetrasaccharide, GlcAβ-GlcN(NS6S)α-GlcAβ-GlcN(NS6S)α was first synthesized as an octyl glycoside. Total synthesis was achieved effectively by coupling the corresponding disaccharide units in short steps.
Graphical abstractRegiospecifically sulfated heparan sulfate tetrasaccharide, GlcAβ-GlcN(NS6S)α-GlcAβ-GlcN(NS6S)α was first synthesized as an octyl glycoside. Total synthesis was achieved effectively by coupling the corresponding disaccharide units in short steps.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlight► Heparan sulfate tetrasaccharides have been synthesized. ► Glycan elongation is available in a stereocontrolled manner. ► Regiospecific N- and O-sulfation of the tetrasaccharide were achieved. ► Unexpected O-sulfation in an aqueous condition was completely suppressed.
