Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1384150 | Carbohydrate Research | 2012 | 4 Pages |
Abstract
The protecting group tetraisopropyldisiloxane-1,3-yl has been investigated for simultaneous protection of two hydroxyls on pentopyranosides. Methyl α-d-xylopyranoside is protected in excellent regioselectivity and high yield to form the 2,3-protected xylopyranoside whereas methyl β-d-xylopyranoside gives the 3,4-protected product also with excellent regioselectivity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new protecting group strategy for pentopyranosides is investigated. ► Simultaneous protection of two hydroxyls of xylosides to form a cyclic protecting group. ► Different regioselectivity is dependent of anomeric configuration.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Richard Johnsson,