Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1384218 | Carbohydrate Polymers | 2009 | 7 Pages |
Abstract
Polysaccharides are widely used as carriers in the field of drug delivery. We present a methodology to obtain water soluble drug-conjugates based on scleroglucan. Selective C-6 halogenation gives access to C-6 esters; conjugates between methotrexate and scleroglucan are described, potentially useful for antitumour therapy or in rheumatoid arthritis treatment.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Francesco Marchetti, Massimo Bergamin, Susanna Bosi, Riaz Khan, Erminio Murano, Stefano Norbedo,