Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1384256 | Carbohydrate Research | 2012 | 6 Pages |
Abstract
Syntheses of six N-homobicyclic dideoxynucleoside analogues are described. The reaction of mannose diacetonide with trimethylsulfoxonium iodide gave a mixture of diastereomeric hydroxymethyl mannose diacetonides in a ratio of 2:5, which was separated by fractional crystallization. The two stereoisomers were converted to bicyclic furanolactols each of which was coupled with three nucleoside bases. Further debenzylations gave the six target N-homobicyclic dideoxynucleosides.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
N. Raghavendra Swamy, N. Suryakiran, P. Paradesi Naidu, Y. Venkateswarlu,