Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1384401 | Carbohydrate Research | 2011 | 6 Pages |
Alkylation of cyclomaltohexaose (α-cyclodextrin, α-CD) with allyl or cinnamyl bromide, followed by peracetylation of remaining hydroxyl groups and separation of isomers, resulted in the set of peracetylated 2I-O-, 3I-O- and 6I-O-alkylated α-CDs in up to 27% yields. Ozonolysis or oxidative cleavage of peracetylated allyl or cinnamyl derivatives resulted in a complete set of peracetylated 2I-O-, 3I-O- and 6I-O-formylmethyl or carboxymethyl derivatives that are useful precursors for preparation of regioselectively monosubstituted derivatives of α-CD. Moreover, a quick method to recognize single 2I-O-, 3I-O- and 6I-O-monosubstituted peracetylated CDs from one another using only their 1H NMR spectra has been proposed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide