Article ID Journal Published Year Pages File Type
1384942 Carbohydrate Polymers 2012 7 Pages PDF
Abstract

In this study, cross-linked hyaluronan-styrylpyridinium (HA-SbQ) micelles were prepared to be used as a novel carrier for paclitaxel (PTX). PTX was successfully encapsulated into the hydrophobic cores of the cross-linked micelles using the dialysis method. The resultant PTX-loaded cross-linked HA-SbQ micelles were about 113 nm in diameter with spherical shape and high encapsulation efficiency. Fluorescence microscopy and high-performance liquid chromatography studies showed that PTX-loaded cross-linked HA-SbQ micelles had excellent cellular uptake ability by bone marrow derived macrophages (BMM) and human glioma U87 cells. Cellular uptake of cross-linked HA-SbQ micelles was found to be higher than that of un-cross-linked ones due to smaller size and more stable structure. In vitro cytotoxicity studies also revealed that the PTX-loaded cross-linked micelles were more potent than those of PTX-loaded un-cross-linked micelles and free PTX. These results suggested that cross-linked HA-SbQ micelles could be a potential vehicle for delivering hydrophobic chemotherapeutic drugs to tumors.

► Cross-linked hyaluronan-styrylpyridinium micelles were prepared. ► Paclitaxel was successfully encapsulated into the cross-linked micelles. ► Paclitaxel-loaded cross-linked micelles had excellent cellular uptake ability. ► Paclitaxel-loaded cross-linked micelles significantly reduced tumor cell viability.

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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