| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1385018 | Carbohydrate Research | 2009 | 8 Pages |
Abstract
A series of β-arabino glycosyl sulfones with varying alkyl chain lengths were synthesised in a stereoselective fashion as putative mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which was maximal for a C-12 chain.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benjamin Ayers, Hilary Long, Edith Sim, Iain A. Smellie, Brendan L. Wilkinson, Antony J. Fairbanks,