The preparation of cellulose nitrate derivatives and their adsorption properties for creatinine

As the sorbent of creatinine, cellulose nitrate (CN) with low degree of nitrification was synthesized from cellulose nitrate by denitration; secondary amine CN (ACN) was synthesized by the reaction of CN, epichlorohydrin and ethylene diamine, and quaternary ammonium CN (CCN) was synthesized by the reaction of CN and 3-chloro-2-hydroxyl-propyltrimethyl ammonium chloride (CHPA). The structures of these three sorbents were studied by elemental analysis and 13C NMR. The adsorption properties for creatinine were evaluated for dialysates with different pH values. At a temperature of 37 °C and a dialysate pH 7.0, the adsorption capacities of ACN, CCN and CN for creatinine were 2.04, 1.47 and 1.08 mg/g, respectively. The adsorption properties of ACN, CCN and CN were not influenced by the content of urea.