Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1385197 | Carbohydrate Polymers | 2006 | 8 Pages |
Chitin has been subjected to regiospecific oxidation at C-6 with NaOCl in the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) and NaBr at room temperature in aqueous solution to yield fully soluble 6-carboxychitin. Several physical and chemical pretreatments of the original chitin changed its crystal structure from α to β. After this pretreatment of the chitin the oxidation was easier to effect and the yield was greatly increased from 36% to 97% and the molecular weight was about 4 × 104 which was ca. 8 times that from the unpretreated chitin. Infrared spectroscopy (IR), X-ray diffraction, 13C NMR and solid-state NMR measurements, and thermal analysis techniques were used to characterize their molecular structures. The moisture absorption and retention abilities of these types of compounds were compared with those of sodium hyaluronan and carboxymethyl chitosan (CMCS) and were found to be superior. They therefore have the potential to substitute for hyaluronan for use in cosmetics and clinical medicine fields.