Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1385219 | Carbohydrate Research | 2008 | 8 Pages |
Abstract
Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Noriyasu Hada, Yukihiko Shida, Hiroshi Shimamura, Yoshiko Sonoda, Tadashi Kasahara, Mutsumi Sugita, Tadahiro Takeda,