Article ID Journal Published Year Pages File Type
1385279 Carbohydrate Polymers 2011 8 Pages PDF
Abstract

Microparticles of crosslinked carboxymethyl pullulan were chemically modified by introducing hydrophobic thermosensitive Poloxamer groups; these new pullulan derivatives are expected to present, besides their ionic character, both amphiphilic and thermosensitive properties. The obtained microparticles were physico-chemically characterized and their interaction with various proteins, such as enzymes (lysozyme, BSA), vaccines (tetanus anatoxin), was studied. The retention/release behavior of the biomolecules on/from the studied derivatives is influenced by electrostatic and hydrophobic forces, as well as by the presence of thermosensitive Poloxamer groups.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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