Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1385279 | Carbohydrate Polymers | 2011 | 8 Pages |
Abstract
Microparticles of crosslinked carboxymethyl pullulan were chemically modified by introducing hydrophobic thermosensitive Poloxamer groups; these new pullulan derivatives are expected to present, besides their ionic character, both amphiphilic and thermosensitive properties. The obtained microparticles were physico-chemically characterized and their interaction with various proteins, such as enzymes (lysozyme, BSA), vaccines (tetanus anatoxin), was studied. The retention/release behavior of the biomolecules on/from the studied derivatives is influenced by electrostatic and hydrophobic forces, as well as by the presence of thermosensitive Poloxamer groups.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Georgeta Mocanu, Doina Mihaï, Virginie Dulong, Luc Picton, Didier Le Cerf, Misu Moscovici,