Comparative 1H NMR and molecular modeling study of hydroxy protons of β-d-Galp-(1→4)-β-d-GlcpNAc-(1→2)-α-d-Manp-(1→O)(CH2)7CH3 analogues in aqueous solution

Systematic modifications at Gal 2-C (H, NHAc, NHPr) and Gal 6-C (H, NH2) resulted in alterations of the Gal 4-OH, Gal 3-OH, and GlcNAc 3-OH areas, as demonstrated by 1H NMR analysis and molecular modeling studies.