| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1385497 | Carbohydrate Research | 2007 | 5 Pages |
Abstract
Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joanna Kubler-Kielb, Evgeny Vinogradov, Chiayung Chu, Rachel Schneerson,