Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1385603 | Carbohydrate Research | 2006 | 7 Pages |
Abstract
The synthesis of new analogues of the naturally occurring glycosidase inhibitor, salacinol, and its ammonium analogue, ghavamiol is described. These analogues contain an additional hydroxymethyl group at C-1, which was intended to form additional polar contacts within the active site of glycosidase enzymes. The target zwitterionic compounds were synthesized by means of nucleophilic attack at the least hindered carbon atom of 2,4-O-benzylidene-l (or d)-erythritol 1,3-cyclic sulfate by 2,5-anhydro-1,3:4,6-di-O-benzylidene-2,5-dideoxy-5-thio (or 1,5-imino)-l-iditol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravindranath Nasi, B. Mario Pinto,