| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1385878 | Carbohydrate Research | 2006 | 6 Pages |
Abstract
Dynamic viscosity (η) of the high-molecular-weight hyaluronan (HA) solution was measured by a Brookfield rotational viscometer equipped with a Teflon cup and spindle of coaxial cylindrical geometry. The decrease of η of the HA solution, indicating degradation of the biopolymer, was induced by a system containing H2O2 alone or H2O2 plus CuCl2. The reaction system H2O2 plus CuCl2 as investigated by EPR spin-trapping technique revealed the formation of a four-line EPR signal characteristic of a DMPO–OH spin adduct. Thus, hydroxyl radicals are implicated in degradation of high-molecular-weight HA by the system containing H2O2 and CuCl2.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ladislav Šoltés, Vlasta Brezová, Monika Stankovská, Grigorij Kogan, Peter Gemeiner,