Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1386905 | Carbohydrate Polymers | 2011 | 8 Pages |
Abstract
This work evaluates the potential of a hot water extracted arabinoxylan from ispaghula (Plantago ovata) seeds as a safe, effective and economical drug carrier. In thermal analysis integral procedural decomposition temperature and comprehensive index of thermal stability were found to be 308 °C and 0.47 respectively. Gel permeation chromatography showed the existence of two components in the fraction. Atomic force microscopy indicated a surface having nanostructure. The tablets incorporating caffeine and diclofenac sodium formulated by the use of arabinoxylan exhibited sustained release profiles in various media. A pH-independent release pattern was observed for caffeine, while for diclofenac sodium the profile was found to be pH-dependent. The arabinoxylan provided a better sustained release as compared with that of Voltral®, a standard diclofenac sodium preparation. The release data suggest Power Law an appropriate model for this system.
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Authors
Mohammad S. Iqbal, Jamshed Akbar, Muhammad A. Hussain, Shazia Saghir, Muhammad Sher,