Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1386954 | Carbohydrate Polymers | 2006 | 8 Pages |
Abstract
Two chitooligosaccharides (COS) derivatives were synthesised by introducing carboxyl (–COCH2CH2COO−) and quaternized amino (–CH2CH(OH)CH2N(CH3)3+) groups to the amino position of COS with different substitution degrees (CCOS-1–3 and QCOS-1–3) for the purpose of altering total amount of hydrogen atoms capable of reacting with radicals and modifying their metal ion chelating ability. Scavenging of carbon-centered and DPPH radicals was directly affected by the amount of abstractable hydrogen atoms in COS molecules. In contrast, structure-activity relationships revealed that chelation of Fe2+ ions indirectly contributed for their observed hydroxyl radical scavenging activity apart from hydrogen abstraction.
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Authors
Ronghua Huang, Niranjan Rajapakse, Se-Kwon Kim,