Synthesis of 6′-deoxy-6′-fluorosucrose

A facile synthesis of 6′-deoxy-6′-fluorosucrose has been developed. The title compound is available in six linear steps in 44% overall yield from commercially available sucrose. The synthesis involves rapid and convenient fluorination and deprotection conditions. This procedure would be very useful for the incorporation of radioactive [18F].

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A synthesis of 6′-deoxy-6′-fluorosucrose is reported. ► A number of different fluorinating agents are useful in this process. ► Fluorination is both rapid and high-yielding, making the process amenable to ‘hot’ chemistry applications.