Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1387791 | Carbohydrate Research | 2015 | 8 Pages |
•Glycosyl halides react with tetrathiomolybdate to give glycosyl dichalcogenides.•Protocol for the synthesis of mixed glycosyl disulfides/selenenylsulfides is reported.•A trisaccharide and a glycosyl amino acid containing mixed disulfide are synthesized.
An easy and mild method has been developed for the synthesis of mixed glycosyl disulfides/selenenylsulfides from glycosyl halides and diaryl/dialkyl dichalcogenides in the presence of benzyltriethylammonium tetrathiomolybdate [(BnEt3N)2MoS4]. The salient feature of this method is the sulfur transfer from [BnEt3N]2MoS4 to form glycosyl disulfides which with excess tetrathiomolybdate further undergo exchange reaction with other dichalcogenides in a one-pot operation.
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