| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1387834 | Carbohydrate Research | 2012 | 5 Pages |
Abstract
A simplified method for the preparation of Fmoc-serine and Fmoc-threonine glycosides for use in O-linked glycopeptide synthesis is described. Lewis acids promote glycoside formation, but also promote undesired reactions of the glycoside products. Use of ‘minimally competent’ Lewis acids such as InBr3 promotes the desired activation catalytically, and with greatly reduced side products from sugar peracetates.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark R. Lefever, Lajos Z. Szabò, Bobbi Anglin, Michael Ferracane, Joanna Hogan, Lauren Cooney, Robin Polt,