| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1387862 | Carbohydrate Research | 2012 | 5 Pages |
Two new phenylethanoid glycosides 1 and 2 named leonoside E and leonoside F, and one new sesquiterpene glycoside (3) identified as 7α (H)-eudesmane-4,11 (12)-diene-3-one-2β-hydroxy-13-β-d-glucopyranoside, together with seven known glycosides (4–10), were isolated from the aerial part of Leonurus japonicus Houtt. Their structures were elucidated on the basis of spectroscopic data and chemical evidence. When tested in in vitro assays, compounds 1, 2, 4, and 6 exhibited potent hepatoprotective activity against d-galactosamine-induced toxicity in HL-7702 cells at concentration of 1 × 10−5 M.
Graphical abstractTwo new phenylethanoid glycosides 1 and 2 named leonoside E and leonoside F, and one new sesquiterpene glycoside 3 identified as 7α (H)-eudesmane-4,11 (12)-diene-3-one-2β-hydroxy-13-β-d-glucopyranoside, together with seven known glycosides (4–10), were isolated from the aerial part of Leonurus japonicus Houtt.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Three new compounds were isolated from Leonurus japonicus Houtt. ► Their structures were identified by spectroscopic data and chemical evidence. ► Compounds 1, 2, 4, and 6 exhibited potent hepatoprotective activity.
