Synthesis of new β2,2-amino acids with carbohydrate side chains: impact on the synthesis of peptides

•Synthesis of new geminally disubstituted C-linked carbo-β2,2-amino acids (β2,2-Caas).•Synthesis of new class of peptides.•Impact of carbohydrate side chains on the synthesis of peptides.•The impact on the absence of C-3 –OMe on the β2,2-peptides.

The study describes the synthesis of new geminally disubstituted C-linked carbo-β2,2-amino acids (β2,2-Caas) with different carbohydrate side chains, and their use in the synthesis of β2,2-peptides. The study infers that the side chain has an influence on the synthesis of peptides and their conformational behaviour.

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