Acyl glycosides lignans, coumarins, and terpenes from the stems of Erycibe obtusifolia

Nine new acyl glycosides, obtusifosides A–I (1–9), and eight known compounds have been isolated from an EtOH extract of the stems of Erycibe obtusifolia. Their structures were elucidated on the basis of a spectroscopic data analysis (NMR, HRESIMS, and CD) and chemical evidence. The hepatoprotective effects of some of the compounds from d-galactosamine-induced cytotoxicity in HL-7702 hepatic cells were evaluated. Compounds 1, 10, 11, 13, 16, and 17 showed significant hepatoprotective activities compared with the positive control bicyclol at concentrations of 1 × 10−5 M.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Nine new acyl glycosides, obtusifosides A–I (1–9) from Erycibe obtusifolia were elucidated. ► Subsequently, their hepatoprotective effects were evaluated and some of them showed significant hepatoprotective activities.