| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1388156 | Carbohydrate Research | 2010 | 6 Pages |
Abstract
A new triterpene glycoside, repandoside (1) was isolated together with six known saponins (2–7) from the methanol extract of Cyclamen repandum tubers. The isolated saponins were characterized by high resolution mass spectrometry and both 1D and 2D NMR experiments. The in vitro effect of saponins on LPS-induced IL-8 and TNF-α mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 μM inhibited the LPS-induced IL-8 and TNF-α expressions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefano Dall’Acqua, Ignazio Castagliuolo, Paola Brun, Federica Ditadi, Giorgio Palù, Gabbriella Innocenti,