Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1388190 | Carbohydrate Research | 2009 | 9 Pages |
Abstract
Preliminary results for the synthesis of two new adenophostin analogues incorporating 3â³- and 4â³-methylenecarboxylate surrogate groups are presented. The synthesis involves the preparation of 3â³- and 4â³-methylenecarboxylate glucose derivatives by a radical allylation-oxidative cleavage approach, their conversion into thioglycoside precursors, and stereoselective glycosylation of a suitable adenosine derivative. The glycosylations proceeded with excellent stereoselectivity, only the α product was detected, and in good yields.
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Organic Chemistry
Authors
David Benito, M. Isabel Matheu, Alain Morère, Yolanda DÃaz, Sergio Castillón,