Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide