| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1388312 | Carbohydrate Research | 2015 | 8 Pages |
•A series of novel artesunate-polyrotaxanes (ATS-PRs) were prepared and characterized.•The ATS-PRs had higher antiproliferative activities than free ATS and DHA.•The ATS-PRs are potentially useful for their application on human colon cancer chemotherapies.
A series of novel artesunate-polyrotaxanes (ATS-PRs) with folic acid capped, in which artesunate (ATS) was covalently bound to a cyclodextrin (CD) of the polyrotaxane (PR), were synthesized and were characterized by NMR, XRD, TG and DSC. The cytotoxicities of ATS-PRs on human colon cancer cell lines HT-29, SW480, HTC116 and DLD-1 showed that their antitumor activities were better than that of artesunate (ATS) and dihydroartemisinin (DHA). These ATS-PRs may provide a useful approach to the development of a highly effective drug candidate for the chemotherapy of human colon cancer.
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