Multivalent glycocyclopeptides: toward nano-sized glycostructures

•Cyclopeptides are attractive scaffolds for the preparation of glycostructures.•Low molecular weight glycoclusters to nano-sized glycodendrimers are described.•Oxime ligation is a powerful strategy to synthesize a variety of glycostructures.•Carbohydrate units are displayed with well-defined spatial orientation.•Relevant recognition properties have been observed with diverse lectins.

Cyclopeptides have recently emerged as attractive molecular scaffolds for the multivalent presentation of carbohydrates in a well-defined constrained spatial orientation. This mini-review describes the last advances on the synthesis and the biological applications of these particular structures, going from low molecular weight glycoclusters to fully synthetic nano-sized glycodendrimers.

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