Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1388449 | Carbohydrate Research | 2011 | 9 Pages |
Abstract
An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry. The supported catalyst avoids the formation of unwanted copper complexes during the cyclisation step. The possibility to graft a pre-chelated M(CO)3 core by click chemistry onto a biomolecule was highlighted for the first time. 99mTc(CO)3-glucoconjugates displayed excellent in vitro stability, a fast in vivo blood clearance and a low specific organ uptake or long-term retention in spleen and stomach.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eric Benoist, Yvon Coulais, Mehdi Almant, José Kovensky, Vincent Moreau, David Lesur, Marine Artigau, Claude Picard, Chantal Galaup, Sébastien G. Gouin,