| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1388504 | Carbohydrate Research | 2017 | 8 Pages |
Abstract
Attempts have been made to find specific antigens for a novel NKT cell subset bearing invariant Vα19-Jα33 TCR α chains (Vα19 NKT cell). Comprehensive examinations revealed substantial antigenic activity in certain α-mannosyl sphingolipids and phosphatidylinositols that were presented by MR1. Structural modification of the sphingosine moiety of α-ManCer improved antigenic activity to enhance either Th1- or Th2-promoting cytokine production by Vα19 NKT cells. Such glycolipids will be useful for developing new therapies as immunomodulators.
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Authors
Michio Shimamura,