Article ID Journal Published Year Pages File Type
1388534 Carbohydrate Research 2010 11 Pages PDF
Abstract

The first total synthesis of caminoside B, a novel marine antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia, was developed. This marine small molecule inhibitor (IC50 = 20 μM) targeting type III secretory pathway of bacterial pathogenesis was assembled in good yield via a ‘2+2+1’ strategy based on stereocontrolled construction of the four glycosidic linkages.

Graphical abstractThe first total synthesis of caminoside B was developed via a ‘2+2+1’ strategy based on stereocontrolled construction of the four glycosidic linkages.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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