Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1388534 | Carbohydrate Research | 2010 | 11 Pages |
Abstract
The first total synthesis of caminoside B, a novel marine antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia, was developed. This marine small molecule inhibitor (IC50 = 20 μM) targeting type III secretory pathway of bacterial pathogenesis was assembled in good yield via a ‘2+2+1’ strategy based on stereocontrolled construction of the four glycosidic linkages.
Graphical abstractThe first total synthesis of caminoside B was developed via a ‘2+2+1’ strategy based on stereocontrolled construction of the four glycosidic linkages.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zaihong Zhang, Chengli Zong, Gaopeng Song, Guokai Lv, Yuexing Chun, Peng Wang, Ning Ding, Yingxia Li,