Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1388572 | Carbohydrate Research | 2008 | 12 Pages |
Abstract
Sperm CD52 GPI anchor and its derivatives containing different carbohydrate chains were prepared in a highly convergent fashion starting from the same properly protected phospholipidated pseudodisaccharide. Coupling this common key intermediate to various oligosaccharyl donors quickly afforded the framework of the synthetic targets, which was followed by global deprotection to furnish the desired structures. Preliminary studies on the biological properties of the synthetic GPI derivatives indicated that both the intact GPI anchor and the free phospholipidated pseudodisaccharide interacted strongly with CAMP factor, a pore-forming bacterial toxin.
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Authors
Xiaoming Wu, Zhihong Shen, Xiangqun Zeng, Shenhui Lang, Michael Palmer, Zhongwu Guo,