Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1388586 | Carbohydrate Research | 2008 | 9 Pages |
Abstract
We describe the synthesis of sugar-fused β-disubstituted γ-butyrolactones, γ-butyrolactams and a lipophilic β-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABAA receptors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ana C. Araújo, Francesco Nicotra, Barbara Costa, Gabriella Giagnoni, Laura Cipolla,