A simple and convenient method for the synthesis of pyranoid glycals

A simple, mild, and environmentally benign synthesis procedure of pyranoid glycals is described. In a novel fashion, protected glycopyranosyl bromides undergo the reductive elimination in the presence of zinc in phosphate buffer at room temperature. The pyranoid glycals were obtained in good-to-excellent yields (18 examples).

Graphical abstractA simple, mild, and environmentally benign synthesis procedure of pyranoid glycals is described. In a novel fashion, protected glycosyl bromides undergo the reductive elimination in the presence of zinc in phosphate buffer at room temperature.Figure optionsDownload full-size imageDownload as PowerPoint slide