Synthesis and antioxidant activity of a novel class of fluorescein-based β-C-glycosides

•Aldol reaction of fluorescein monoaldehyde with β-C-glycosylic ketones.•All the compounds were characterized using different spectral techniques.•Fluorescein-based β-C-glycosides exhibited moderate antioxidant activities.

A series of fluorescein-based β-C-glycosyl ketones were synthesized through aldol condensation of β-C-glycosyl ketones with fluorescein monoaldehyde under ambient reaction conditions in good yields. Formation of the expected product has been confirmed through different spectral techniques. Fluorescein-based β-C-glycosides show moderate anti-oxidant activities with maximum inhibitory activity of 60%.

Graphical abstractA series of fluorescein-based β-C-glycosyl ketones were synthesized through aldol condensation of β-C-glycosyl ketones with fluorescein monoaldehyde under ambient reaction conditions in good yields. Formation of the expected product has been confirmed through different spectral techniques. Fluorescein-based β-C-glycosides show moderate anti-oxidant activities with maximum inhibitory activity of 60%.Figure optionsDownload full-size imageDownload as PowerPoint slide